[Stroke] Investigators explored the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors, and mesenchymal stem cells.

[Pigment Cell & Melanoma Research] Using a cell enrichment strategy to isolate KIT+/CD45− cells from the telogen skin of adult female C57BL/6J mice, investigators evaluated the transcriptional landscape of quiescent melanocyte stem cells at high resolution.

[PLOS One] A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.

[European Journal Of Clinical Investigation] Scientists investigated how ECM composition modulated CD8+ T cell function in undifferentiated pleomorphic sarcoma, an immunologically active desmoplastic tumor.

[Advanced Materials] Bottlebrush polymers were synthesized and crosslinked to form poly(ethylene glycol)-based hydrogels and used to study how strain-stiffening behavior affects human MSCs.

[Journal Of Cellular And Molecular Medicine] Scientists investigated the anti-acute myelogenous leukemia (AML) activity of bortezomib, emphasizing its anti-leukemic stem cells potential, using KG-1a cells, an AML cell line with stem-like properties.

[Cell Reports Medicine] The authors performed ex vivo drug screening of CML CD34+ leukemic stem/progenitor cells using 100 single drugs and tyrosine kinase inhibitor-drug combinations and identify sensitivities to Wee1, MDM2, and BCL2 inhibitors.

[Hubrecht Institute] Delilah Hendriks, researcher from the Organoid group, Oncode researcher, and affiliated group leader at the Princess Máxima Center has received a Young Investigator Grant from the Dutch Cancer Society.

[Biochemical Pharmacology] Scientists tested whether hypertensive pregnancy involved localized aberrations in uterine arterial tone, stiffness and remodeling by matrix metalloproteinases.

[International Immunopharmacology] The authors showed that Tn64 bound to Tn fn repeats 3–5. Unlike other Tn fn domains, Tn fn 3–5 displayed no inhibition of fibronectin matrix assembly.

[European Journal Of Applied Physiology] Scientists examined how proteolysis-related biomarkers and ECM remodeling factors respond to a bout of resistance training in the untrained and trained state.

[Phytotherapy Research] A collagen-induced arthritis rat model and tumor necrosis factor alpha-induced fibroblast-like synoviocytes were utilized to investigate the inhibitory effect of Sophoridine on hreumatoid arthritis.